Mineralocorticoid receptor antagonism: therapeutic potential in acute heart failure syndromes
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor antagonism: therapeutic potential in acute heart failure syndromes.
Acute heart failure syndromes (AHFS) are a heterogeneous group of commonly encountered and difficult to manage clinical syndromes associated with high morbidity and mortality. Dyspnoea, pulmonary, and systemic congestion often characterize AHFS due to acutely elevated intracardiac filling pressures and fluid overload. Diuresis, respiratory support, vasodilator therapy, and gradual attenuation o...
متن کاملMineralocorticoid receptor antagonism in acutely decompensated chronic heart failure.
BACKGROUND/OBJECTIVES Mineralocorticoid receptor antagonist (MRA) use in acutely decompensated chronic heart failure (ADCHF) may improve congestion through diuretic effect and prevent neurohormonal activation. We aimed to evaluate the clinical effect and safety of spironolactone in ADCHF. METHODS Prospective, experimental, single-center, and single-blinded trial. Patients were treated with: s...
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Heart failure resulting in hospitalization represents a significant and growing health care burden. Heterogeneity characterizes this group in terms of mode of presentation, pathophysiology, and prognosis. The vast majority of patients symptomatically improve during hospitalization; however, their early post-discharge rehospitalization and mortality rates continue to be high. Worsening signs and...
متن کاملInteractions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure.
BACKGROUND Mineralocorticoid receptor antagonists (MRAs) have become established therapy in heart failure (HF). Urocortin 2 (Ucn2) is a novel peptide with potential in the treatment of this disease. The present study investigated the interactions of acute administration of Ucn2 and an MRA in experimental HF. METHODS AND RESULTS Ucn2 and an MRA (canrenoic acid [CA]) were infused for 4 hours, b...
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There are three key elements to any clinical trial: study population, study intervention, and outcome. The REMINDER study reported by Montalescot et al., is worth considering in detail because of how the investigators ultimately decided these three questions: the choice of ST-segment elevation myocardial infarction (STEMI) patients without heart failure as the population of interest, the select...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2011
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehr170